TABLE 8

Impact of AKI by NT2× on mortality, adjusted for potential confounders

Variables by model typeaOR/HR (95% CI)bP value
Logistic regression model
    Unadjusted
        NT2×2.94 (1.41–6.14)0.004
    Model 1
        NT2×2.279 (1.007–5.16)0.048
        Charlson index (≥4 vs 0–3)2.694 (1.104–6.11)0.033
        Steroids2.960 (1.225–7.15)0.019
        Vancomycin2.715 (1.193–6.18)0.016
        Furosemide2.597 (1.104–6.11)0.029
    Model 2
        NT2×1.06 (0.32–3.55)0.927
        Steroids6.06 (1.59–23.02)0.008
        Vasopressors3.60 (0.99–13.09)0.052
        Mechanical ventilation44.34 (12.28–160.02)<0.001
Cox regression model
    Unadjusted
        NT2×2.23 (1.23–4.03)0.008
    Model 1
        NT2×2.31 (1.27–4.19)0.006
        Charlson index (≥4 vs 0–3)2.04 (1.07–3.91)0.031
        Steroids2.12 (1.02–4.42)0.044
    Model 2
        NT2×1.27 (0.68–2.35)0.453
        Steroids2.14 (1.02–4.47)0.044
        Vasopressors2.20 (1.02–4.02)0.045
        Mechanical ventilation5.49 (2.40–12.56)<0.001
  • a NT2×, traditional nephrotoxicity criterion of an SCr increase of ≥2× over baseline. Variables included in model 1: first block (backward) Charlson's comorbidity index, use of furosemide, vancomycin, and steroids; second block (enter) AKI by NT2×. Variables included in model 2: first block (backward) all variables included in model 1 plus ICU, use of vasopressors, and mechanical ventilation; second block (enter) AKI by NT2×.

  • b Odds ratio (OR) was used for logistic regression data and hazard ratio (HR) for Cox regression data. 95% CI, 95% confidence interval.