TABLE 1

Patient demographics

Patient parameterResult(s)aPb
Group 1 (n = 22)Group 2 (n = 33)All patients (n = 55)
Male/female, n (%)14/8 (64/36)29/4 (88/12)43/12 (78/22)0.035
Age, yr, median (IQR)36 (24–43)44 (30–57)39 (29–51)0.052
Wt, kg56.5 (16.6)65.9 (15.6)62.2 (16.5)0.011
Lean body mass, kg52.2 (10.6)61.8 (8.8)58.0 (10.6)0.001
Ht, m1.70 (0.09)1.73 (0.08)1.72 (0.08)0.115
Body mass index, kg/m219.7 (5.8)22.0 (5.0)21.1 (5.4)0.037
Body surface area, m21.63 (0.22)1.80 (0.21)1.74 (0.23)0.012
Dose, mg614 (130)595 (26.1)602 (84.1)0.844
Dose/wt, mg/kg11.4 (3.2)9.40 (1.8)10.2 (2.6)0.008
Ethnicity, n (%)0.081c
    Black11 (50)10 (30)21 (38)
    Caucasian4 (18)14 (42)18 (33)
    Asian1 (5)5 (15)6 (11)
    Other6 (27)4 (12)10 (18)
Type of tuberculosis, n (%):0.089c
    Pulmonary12 (55)27 (82)39 (71)
    Extrapulmonary6 (27)4 (12)10 (18)
    Both4 (18)2 (6)6 (11)
Comorbidity, present n (%)4 (18)13 (39)17 (31)0.095c
Comedication, present n (%)7 (32)26 (79)33 (60)0.000c
Samples/patient, n (%)6.5 (1.3)10.3 (0.9)8.8 (2.2)0.000
Sampling schedulePredose and random times between 0.5 and 8 h postdosePredose and 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 12.0, and 24.0 h postdose
  • a Data are presented as means (SD), unless stated otherwise. IQR, interquartile range.

  • b Continuous data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.

  • c Chi-square test.