TABLE 2

Noncompartmental pharmacokinetic parameters of rifampina

Pharmacokinetic parameterValuesaPb
Group 1 (n = 22)Group 2 (n = 33)All patients (n = 55)
AUC0–24 (mg · h/liter)35.2 (23.9–109)46.3 (13.5–117)41.5 (13.5–117)0.007
Cmax (mg/liter)6.8 (3.5–15.6)9.3 (2.4–24.1)8.2 (2.4–24.1)0.002
Tmax (h)2.6 (0.5–4.5)2.0 (0.4–5.7)2.2 (0.4–5.7)0.069
CL/F (liter/h)17.5 (10.0–31.5)13.0 (4.9–51.3)14.7 (4.9–51.3)0.013
V/F (liter)51.9 (25.5–103)41.5 (12.8–182)45.4 (12.8–182)0.054
t1/2 (h)1.9 (0.7–2.4)2.2 (1.6–6.6)2.1 (0.7–6.6)0.559
  • a Data are presented as geometric mean (range), except for the Tmax data, which are displayed as median (range). AUC0–24, area under the concentration-time curve from 0 to 24 h in milligrams × hour per liter; Cmax, maximum concentration in mg per liter; Tmax, time to maximum concentration in hours; CL/F, apparent clearance in liters per hour; V/F, apparent volume of distribution in liters; t1/2, elimination half-life in hours. F, bioavailability.

  • b Data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.