Pharmacokinetic parameter | Values^{a} | P^{b} | ||
---|---|---|---|---|

Group 1 (n = 22) | Group 2 (n = 33) | All patients (n = 55) | ||

AUC_{0–24} (mg · h/liter) | 35.2 (23.9–109) | 46.3 (13.5–117) | 41.5 (13.5–117) | 0.007 |

C_{max} (mg/liter) | 6.8 (3.5–15.6) | 9.3 (2.4–24.1) | 8.2 (2.4–24.1) | 0.002 |

T_{max} (h) | 2.6 (0.5–4.5) | 2.0 (0.4–5.7) | 2.2 (0.4–5.7) | 0.069 |

CL/F (liter/h) | 17.5 (10.0–31.5) | 13.0 (4.9–51.3) | 14.7 (4.9–51.3) | 0.013 |

V/F (liter) | 51.9 (25.5–103) | 41.5 (12.8–182) | 45.4 (12.8–182) | 0.054 |

t_{1/2} (h) | 1.9 (0.7–2.4) | 2.2 (1.6–6.6) | 2.1 (0.7–6.6) | 0.559 |

↵a Data are presented as geometric mean (range), except for the

*T*_{max}data, which are displayed as median (range). AUC_{0–24}, area under the concentration-time curve from 0 to 24 h in milligrams × hour per liter;*C*_{max}, maximum concentration in mg per liter;*T*_{max}, time to maximum concentration in hours; CL/F, apparent clearance in liters per hour;*V*/F, apparent volume of distribution in liters;*t*_{1/2}, elimination half-life in hours. F, bioavailability.↵b Data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.