Pharmacokinetic parameter | Values for all patients (n = 55) |
---|---|

CL_{m}/F (liters/h/1.85 m^{2}) | 15.5 (8.0) |

f_{r} | 0.14 (fixed) |

V/F (liters/kg LBM) | 0.713 (0.282) |

k (1/h)_{a} | 1.14 (1.03) |

T_{lag} (h) | 0.887 (0.571) |

F | 1 (fixed) |

↵a Data are presented as population mean (SD). Bioavailability (F) was fixed at a value of 1, and the rifampin clearance/creatinine clearance ratio (

*f*) was fixed at a value of 0.14. CL_{r}_{m}/F, apparent metabolic clearance in liters per hour normalized to a body surface area of 1.85 m^{2};*V*/F, apparent volume of distribution in liters per kilogram of lean body mass (LBM);*k*, absorption rate constant in 1/h;_{a}*T*_{lag}, lag time in the absorption phase in hours.