Pharmacokinetic parameter | Values | P^{b} | |
---|---|---|---|

Group 1 (n = 22) | Group 2 (n = 33) | ||

CL_{m}/F (liters/h/1.85 m^{2}) | 17.9 (9.1–32.9) | 13.8 (5.4–54.3) | 0.035 |

V/F (liters/kg LBM) | 0.844 (0.545–1.514) | 0.637 (0.325–1.162) | 0.002 |

k (1/h)_{a} | 0.90 (0.22–3.24) | 1.33 (0.26–5.37) | 0.078 |

T_{lag} (h) | 1.11 (0.46–2.92) | 0.77 (0.30–2.12) | 0.017 |

↵a Data are presented as geometric mean (range). CL

_{m}/F, apparent metabolic clearance in liters per hour normalized to a body surface area of 1.85 m^{2};*V*/F, apparent volume of distribution in liters per kg of lean body mass;*k*, absorption constant in 1/h;_{a}*T*_{lag}, lag time in the absorption phase in hours.↵b Data from comparisons of groups 1 and 2 were tested using the Mann-Whitney U test.