TABLE 5

Best-performing optimal sampling strategies for one, two, and three time points

First sampling time point (h)Second sampling time point (h)Third sampling time point (h)Correlation coefficient (r)Mean predictive error (% bias)% RMSEa
70.833.827.4
60.830.527.6
80.835.727.9
50.81−4.229.0
90.816.929.1
3100.93−3.218.3
280.920.318.7
390.93−4.418.8
270.92−2.818.8
380.93−5.219.0
1380.96−0.413.2
24100.96−2.714.0
2490.96−3.614.0
1390.96−0.614.2
25140.96−2.314.3
  • a RMSE, root mean square error.