TABLE 6

Comparative pharmacokinetic parameters of DAQ in female and male patients with uncomplicated malaria

ParameterValue (mean ± SD) (n = 3/group)P value
FemaleMale
Cmax (ng/ml)740 ± 197767 ± 1850.872
Tmax (h)48.048.0
T1/2 (h)212 ± 1.14214 ± 0.840.093
AUC0–t (h · ng/ml)120,840 ± 15,962119,750 ± 11,2410.928
AUC0–∞ (h · ng/ml)185,080 ± 20,813184,940 ± 16,3700.993
AUC on day 7 (h · ng/ml)73,790 ± 9,66974,153 ± 7,6310.962
Concn on day 7 (ng/ml)350 ± 63.5332 ± 27.90.667