TABLE 2

Summary statistics for population PK parameters estimated with NPAG algorithma

Parameterka (h−1)ki (h−1)ks (h−1)k12 (h−1)k21 (h−1)k23 (h−1)k32 (h−1)Vplasma (liters)VELF (liters)VAC (liters)
Mean2.571.3720.8009.5849.8999.26611.27651.349.953.7
SD1.3640.6936.4686.8697.7727.82044.546.042.0
Median0.7610.7129.2509.8607.43511.33422.730.339.7
25th percentile0.3530.1363.5933.7310.5722.73812.710.714.2
75th percentile1.8081.38014.16016.46617.85219.718102.6117.295.4
  • a The ka value was fixed from literature data. The elimination rate constant (ke) for slow acetylators is equal to ki. The elimination rate constant for fast acetylators is equal to ki + ks (mean, 2.172 h−1).