TABLE 2

Distribution of serogroups/types of noninvasive S. pneumoniae collected during 2009 to 2012 in the United States

Serogroup/type(s)aNo. (%) by yrNo. (%) for all yrs
2009201020112012
PCV725 (4.6)38 (5.5)47 (5.0)37 (5.0)147 (5.0)
    19F15 (2.7)24 (3.5)31 (3.3)25 (3.4)95 (3.2)
    9V/9A3 (0.5)0 (0.0)6 (0.6)2 (0.3)11 (0.4)
    23F2 (0.4)4 (0.6)2 (0.2)3 (0.4)11 (0.4)
    6B2 (0.4)2 (0.3)4 (0.4)2 (0.3)10 (0.3)
    18 (18A/18B/18C/18F)3 (0.5)2 (0.3)0 (0.0)2 (0.3)7 (0.2)
    140 (0.0)4 (0.6)1 (0.1)2 (0.3)7 (0.2)
    40 (0.0)2 (0.3)3 (0.3)1 (0.1)6 (0.2)
PCV13*195 (35.5)232 (33.7)319 (33.8)210 (28.2)956 (32.7)
    19A88 (16.0)109 (15.8)161 (17.1)91 (12.2)449 (15.3)
    350 (9.1)60 (8.7)84 (8.9)64 (8.6)258 (8.8)
    7F*21 (3.8)22 (3.2)24 (2.5)13 (1.7)80 (2.7)
    6A*11 (2.0)3 (0.4)3 (0.3)5 (0.7)22 (0.8)
    10 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)
    50 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)
PPSV23-nonPCV13134 (24.4)172 (25.0)229 (24.3)197 (26.4)732 (25.0)
    11A/11D34 (6.2)41 (6.0)49 (5.2)44 (5.9)168 (5.7)
    22A/22F31 (5.6)36 (5.2)49 (5.2)35 (4.7)151 (5.2)
    15B/15C*15 (2.7)36 (5.2)47 (5.0)47 (6.3)145 (5.0)
    9N/9L12 (2.2)22 (3.2)26 (2.8)21 (2.8)81 (2.8)
    17F14 (2.6)11 (1.6)15 (1.6)11 (1.5)51 (1.7)
    10A13 (2.4)6 (0.9)20 (2.1)11 (1.5)50 (1.7)
    33F/33A/377 (1.3)8 (1.2)14 (1.5)12 (1.6)41 (1.4)
    202 (0.4)6 (0.9)3 (0.3)9 (1.2)20 (0.7)
    84 (0.7)4 (0.6)5 (0.5)6 (0.8)19 (0.6)
    12F/12A/44/462 (0.4)2 (0.3)1 (0.1)1 (0.1)6 (0.2)
Nonvaccine*207 (37.7)271 (39.4)374 (39.6)324 (43.4)1,176 (40.2)
    6C/6D45 (8.2)40 (5.8)64 (6.8)54 (7.2)203 (6.9)
    35B*20 (3.6)45 (6.5)75 (7.9)61 (8.2)201 (6.9)
    23A31 (5.6)32 (4.7)54 (5.7)46 (6.2)163 (5.6)
    15A/15F30 (5.5)40 (5.8)44 (4.7)34 (4.6)148 (5.1)
    23B22 (4.0)22 (3.2)37 (3.9)43 (5.8)124 (4.2)
    16F15 (2.7)23 (3.3)22 (2.3)16 (2.1)76 (2.6)
    3113 (2.4)18 (2.6)23 (2.4)20 (2.7)74 (2.5)
    346 (1.1)17 (2.5)12 (1.3)11 (1.5)46 (1.6)
    35F/47F10 (1.8)10 (1.5)11 (1.2)8 (1.1)39 (1.3)
    7C/7B/405 (0.9)12 (1.7)10 (1.1)7 (0.9)34 (1.2)
    133 (0.5)4 (0.6)3 (0.3)8 (1.1)18 (0.6)
    213 (0.5)2 (0.3)6 (0.6)7 (0.9)18 (0.6)
    38/25F/25A1 (0.2)2 (0.3)9 (1.0)5 (0.7)17 (0.6)
    Other3 (0.5)4 (0.6)4 (0.4)4 (0.5)15 (0.5)
Nontypeable13 (2.4)13 (1.9)22 (2.3)15 (2.0)63 (2.2)
All549 (100.0)688 (100.0)944 (100.0)746 (100.0)2,927 (100.0)
  • a Differences in serotype prevalence rates over time were assessed by calculating the P values by the chi-square test for trends using Epi Info, version 7.1.1.14. *, calculated P values were <0.05 and were considered statistically significant. “Nonvaccine” indicates those strains not present in the three vaccines available in the United States.