TABLE 3

Distribution of vaccine types of noninvasive S. pneumoniae isolates according to subject age group during 2009 to 2012 in the United States

Vaccine typea by age group (yrs)No. (%) by yrNo. (%) for all yrs
2009201020112012
PCV725 (4.6)38 (5.5)47 (5.0)37 (5.0)147 (5.0)
    18–497 (28.0)9 (23.7)16 (34.0)14 (37.8)46 (31.3)
    50–6411 (44.0)10 (26.3)16 (34.0)7 (18.9)44 (29.9)
    ≥657 (28.0)19 (50.0)15 (31.9)16 (43.2)57 (38.8)
PCV13195 (35.5)232 (33.7)319 (33.8)210 (28.2)956 (32.7)
    18–4964 (32.8)74 (31.9)118 (37.0)68 (32.4)324 (33.9)
    50–6458 (29.7)82 (35.3)99 (31.0)79 (37.6)318 (33.3)
    ≥6573 (37.4)76 (32.8)102 (32.0)63 (30.0)314 (32.8)
PPSV23-nonPCV13134 (24.4)172 (25.0)229 (24.3)197 (26.4)732 (25.0)
    18–49*53 (39.6)65 (37.8)75 (32.8)59 (29.4)252 (34.4)
    50–6445 (33.6)49 (28.5)77 (33.6)75 (38.1)246 (33.6)
    ≥6536 (26.9)58 (33.7)77 (33.6)63 (32.0)234 (32.0)
Nonvaccine207 (37.7)271 (39.4)374 (39.6)324 (43.4)1,176 (40.2)
    18–4963 (30.4)99 (36.5)119 (31.9)106 (32.7)387 (32.9)
    50–6468 (32.9)88 (32.5)128 (34.2)109 (33.6)393 (33.4)
    ≥6576 (36.7)84 (31.0)127 (34.0)109 (33.6)396 (33.7)
Nontypeable13 (2.4)13 (1.9)22 (2.3)15 (2.0)63 (2.2)
    18–495 (38.5)3 (23.1)8 (36.4)4 (26.7)20 (31.7)
    50–64*7 (53.8)6 (46.2)7 (31.8)2 (13.3)22 (34.9)
    ≥65*1 (7.7)4 (30.8)7 (31.8)9 (60.0)21 (33.3)
All549 (100.0)688 (100.0)944 (100.0)746 (100.0)2,927 (100.0)
  • a Differences in serotype prevalence rates over time were assessed by calculating the P values by the chi-square test for trends using Epi Info, version 7.1.1.14. *, calculated P values were <0.05 and were considered statistically significant. “Nonvaccine” indicates those strains not present in the three vaccines available in the United States.