TABLE 2

Fold changes in MICs for OP0595-selected mutants (n = 93) of the fully susceptible parent control strains (n = 19)

Fold change in MICaNo. of mutants with the indicated fold change in MICb
OP0595PiperacillinCefepimeAztreonamMeropenemCeftazidimeImipenemAmdinocillinAmikacin
0.061
0.12251
0.251041034
0.532242042125
1 (no change)374742464412144
29111632212011
425113375
8212212
165c121
3240c12
6441c3
1285c5
25617
>25664
  • a Calculated as the MIC for the mutant/MIC for the parent.

  • b The numbers of mutants with no change in the MIC for the different drugs are shown in bold type.

  • c Minimum values for fold change as most MICs for mutants were above the highest concentration of OP0595 tested (32 µg/ml).