TABLE 3

MIC distributions of diazabicyclooctane combinations for 93 OP0595-selected mutants of 19 control strains

MIC (μg/ml) or parameterNo. of mutants with the indicated MICs (μg/ml) for drug alone or in combinationa:
Piperacillin + OP0595Cefepime + OP0595Aztreonam + OP0595Meropenem + OP0595Ceftazidime
0248024801240248Alone+AVI
≤0.016675198386878434850174856553
0.032310391076112222225933252715
0.061182013192719171716111210826
0.1224232914368531112232
0.253262924281112822
0.561410113234
11231191
226
4191
8181
166
321
641
GMb2.770.1460.1270.1240.038≤0.016≤0.016≤0.0160.0780.0280.0250.0240.0300.0220.0210.0210.2550.112
  • a The MIC distribution of drugs alone or in combination with the OP0595 diazabicyclooctane is shown as the number of mutants with the indicated MICs. All MICs are shown in micrograms per milliliter. The MICs of the drugs (e.g., piperacillin, cefepime, etc.) were determined in the presence of OP0595 at 2, 4, and 8 μg/ml (0 for no OP0595). The MIC distribution of ceftazidime alone and with avibactam (+AVI) (4 μg/ml) is shown for comparison. Modal MICs are indicated in bold type.

  • b GM, geometric mean. MICs of >256 μg/ml were counted as 512 μg/ml when calculating the geometric means, and MICs of ≤0.016 were counted as 0.014 μg/ml.