TABLE 1

Nonsynonymous mutations observed in the K13 gene in P. falciparum isolates from Dakar, Senegal, collected from November 2013 to January 2014 and August 2014 to December 2014a

Amino acid change or insertion and locationBladedReferent sequenceMutant sequencebNo. of isolates/total isolates (%)
K123RcAAAAGA1/58 (1.7)
N137ScAATAGT1/58 (1.7)
N142NNAAT7/58 (12.1)
N142NNNAAT AAT1/58 (1.7)
T149SACTTCT1/58 (1.7)
K189TAAAACA18/58 (31.0)
K189NcAAAAAT1/58 (1.7)
N554H3AATCAT1/92 (1.1)
Q613Hc4CAACAT1/92 (1.1)
V637I5GTTATT3/92 (3.3)
  • a Mutations described were not found in the same isolates.

  • b Mutated bases are in bold type.

  • c Novel mutation.

  • d —, absence of blade numbered only in the propeller domain.