TABLE 1

Summary of animal weight loss, urine output, histopathology scores, and vancomycin exposure estimatesa

CharacteristicOne-day protocolThree-day protocol
ControlVancomycinP valueControlVancomycinP value
No. of animals in group/total no. of animals5/5222/525/5220/52
Mean ± SD wt loss (g)25.6 ± 4.021.5 ± 9.40.3526.6 ± 3.625.3 ± 12.70.82
Mean ± SD urine output (ml)NR10.6 ± 5.3bc13.6 ± 2.312.8 ± 6.7d0.79
Median (IQR) worst composite score2 (2–2)2 (1–2)0.681 (1–2)2 (1–3)0.41
Median (IQR) AUC0–24 (μg · h/ml)0112 (62.2–292)0202 (83.1–248)
Median (IQR) Cmax0–24 (μg/ml)017.5 (8.7–57.6)026.4 (13.9–51.8)
Median (IQR) Cmin0–24 (μg/ml)00.04 (0.0–2.5)01.8 (0.0–3.2)
  • a Urinary, histopathological, and PK exposure endpoints were stratified by experimental condition (i.e., vancomycin or saline control) and protocol duration (1 or 3 days). Abbreviations: AUC0–24, area under the concentration time curve during the first 24 h; Cmax0–24, maximal concentration during the first 24 h; Cmin0–24, lowest (minimum) concentration after the dose closest to 24 h; IQR, interquartile range. NR, data were not recorded.

  • b  Data are for 21 rats.

  • c  —, statistical testing against a zero value was not performed.

  • d  Data are for 17 rats.