Parameter | Mean | Median | SD | CV (%) |
---|---|---|---|---|

K (h_{a}^{−1}) | 1.5 | 1.0 | 1.3 | 84.8 |

V_{0}/F (liter/0.3 kg) | 0.3 | 0.3 | 0.2 | 54.0 |

k_{el}/F (h^{−1}) | 1.3 | 0.9 | 0.9 | 73.8 |

K_{12} (h^{−1}) | 4.8 | 1.9 | 5.3 | 110.3 |

K_{21} (h^{−1}) | 4.2 | 1.6 | 5.3 | 124.8 |

↵a Mean and median population pharmacokinetic parameters along with their attendant measures of dispersion are presented. The PK model was derived from 276 observations in 42 animals. Abbreviations: CV, coefficient of variation;

*K*, intercompartmental absorption rate from the peritoneal space to the central compartment;_{a}*k*_{el}, central compartment elimination rate;*K*_{12}and*K*_{21}, intercompartmental mass transfer rates between the central and peripheral compartments;*V*_{0}, volume of distribution standardized to a 0.3-kg body weight;*F*, apparent bioavailability of clearance and volume, which was not estimated [i.e., CL/*F*= (*V*_{0}·*k*_{el})/*F*].