TABLE 2

Final three-compartment population PK model estimatesa

ParameterMeanMedianSDCV (%)
Ka (h−1)1.51.01.384.8
V0/F (liter/0.3 kg)0.30.30.254.0
kel/F (h−1)1.30.90.973.8
K12 (h−1)4.81.95.3110.3
K21 (h−1)4.21.65.3124.8
  • a Mean and median population pharmacokinetic parameters along with their attendant measures of dispersion are presented. The PK model was derived from 276 observations in 42 animals. Abbreviations: CV, coefficient of variation; Ka, intercompartmental absorption rate from the peritoneal space to the central compartment; kel, central compartment elimination rate; K12 and K21, intercompartmental mass transfer rates between the central and peripheral compartments; V0, volume of distribution standardized to a 0.3-kg body weight; F, apparent bioavailability of clearance and volume, which was not estimated [i.e., CL/F = (V0 · kel)/F].