TABLE 2

Sequence, MIC, and average percent reduction of envelope integrity relative to that for polymyxin B for the two best peptide hits detected by the envelope integrity screen

Compound no.Peptide sequenceMIC (μM)aAvg ± SD % reductionbP value
79KKWRKWLKWLAKK-NH22236 ± 850.03
33KWKLFKKVLKVLTTG-NH22166 ± 440.09
  • a MIC for Escherichia coli reference strain ATCC 25922.

  • b Average envelope integrity reduction based on three biological replicates.