TABLE 3

Growth or no growth of Escherichia coli ATCC 25922 in the presence of peptide-antibiotic combinations

AntibioticaMICb (μg/ml)Antibiotic concn (μg/ml)Growthc
Compound 79Compound 33No peptide
PEN162d+++
ERY160.5e++
FUS5001f+
NOV161g+
RIF20.5e+
VAN2504h+++
No antibioticNAiNA+++
  • a PEN, benzylpenicillin; ERY, erythromycin; FUS, fusidic acid; NOV, novobiocin; RIF, rifampin; VAN, vancomycin.

  • b MICs of antibiotics individually.

  • c Compounds 79 and 33 were tested at a concentration of 1 μM each. +, growth; −, no growth.

  • d EUCAST generic breakpoint.

  • e EUCAST breakpoints for Streptococcus spp.

  • f EUCAST breakpoints for Staphylococcus spp.

  • g Arbitrary breakpoint defined in the absence of any clinical breakpoint.

  • h EUCAST breakpoint for Enterococcus spp.

  • i NA, not applicable.