TABLE 1

Baseline characteristics of patients with M. avium complex lung disease or M. abscessus complex lung diseasea

CharacteristicbM. avium complexM. abscessus complex (n = 55)
Total (n = 166)Daily therapy (n = 77)Intermittent therapy (n = 89)P value
Sex, male68 (41.0)33 (42.9)35 (39.3)0.64516 (29.1)
Age (yr)61 (52–69)59 (51–70.5)61 (52.5–68.5)0.70756 (50–64)
Body mass index (kg/m2)20.1 (18.5–21.8)19.8 (17.5–21.2)20.7 (19.0–22.2)0.00320.5 (19.1–22.3)
Nonsmoker163 (98.2)75 (97.4)88 (98.9)0.59753 (96.4)
Comorbid disease
    Bronchiectasis137 (82.5)52 (67.5)85 (95.5)<0.00145 (81.8)
    Previous tuberculosis80 (48.2)49 (63.6)31 (34.8)<0.00137 (67.3)
    Previous NTM lung disease25 (15.1)13 (16.9)12 (13.5)0.5416 (10.9)
    Cancer33 (19.9)16 (20.8)17 (19.1)0.7874 (7.3)
    Chronic lung diseasec11 (6.6)9 (11.7)2 (2.2)0.0153 (5.5)
    Diabetes mellitus10 (6.0)4 (5.2)6 (6.7)0.7530
    Chronic liver disease8 (4.8)5 (6.5)3 (3.4)0.4743 (5.5)
    Chronic heart disease5 (3.0)2 (2.6)3 (3.4)1.0004 (7.3)
    Chronic kidney disease2 (1.2)1 (1.3)1 (1.1)1.0000
Etiology
    Mycobacterium avium87 (52.4)36 (46.8)51 (57.3)0.175
    Mycobacterium intracellulare79 (47.6)41 (53.2)38 (42.7)
    Mycobacterium abscessus25 (45.5)
    Mycobacterium massiliense30 (54.5)
Type of disease
    Fibrocavitary form26 (15.7)26 (33.8)0<0.00112 (21.8)
    Nodular bronchiectatic form132 (79.5)47 (61.0)85 (95.5)42 (76.4)
    Unclassifiable form8 (4.8)4 (5.2)4 (4.5)1 (1.8)
Cavity on chest HRCTd66 (39.8)66 (85.7)0<0.00129 (52.7)
Positive sputum smeard76 (45.8)53 (68.8)23 (25.8)<0.00139 (70.9)
  • a Data are presented as median (interquartile range) or as number (%).

  • b NTM, nontuberculous mycobacteria; HRCT, high-resolution computed tomography.

  • c Chronic lung disease included chronic obstructive pulmonary disease (n = 5), interstitial lung disease (n = 2), and chronic pulmonary aspergillosis (n = 9). Some patients had more than one chronic lung disease.

  • d At the initiation of antibiotic treatment.