TABLE 3

CI calculations for EDP-239 combinations

EDP-239 combinationMean CIa
EC50EC75EC90EC95
Alisporivir0.750.540.410.34
Simeprevir0.850.680.550.47
Sofosbuvir0.680.560.470.41
Interferon alpha1.091.000.940.90
  • a The mean combination index (CI) was calculated by averaging the EC50, EC75, EC90, and EC95 values across five drug ratios of each 8 × 8 combination synergy surface, representing an average of four biological replicates. CI of 0.9 to 1.1 = additive; CI of >1.1 = antagonistic; CI of <0.9 = synergistic.