TABLE 4

Mean plasma pharmacokinetic parameters of EDP-239 in GT1 HCV-infected patientsa

EDP-239 dose (mg)No. of patientsAUC0–inf (h · ng/ml)Cmax (ng/ml)Tmax (h)t1/2 (h)CL/F (ml/h)
1062,270 (61.5)95.8 (36.4)1.75 (1.50, 3.00)25.1 (29.6)5620 (47.7)
3067,460 (55.6)305 (23.4)2.02 (1.50, 4.00)25.0 (31.7)5000 (47.7)
100621,800 (29.9)849 (36.1)2.51 (2.00, 4.00)23.0 (22.4)5080 (40.7)
200669,500 (50.6)2170 (33.2)3.00 (2.00, 5.00)22.9 (35.8)3330 (33.5)
  • a All values (except Tmax) are means, with the coefficient of variation (%) given in parentheses. Tmax values are medians, with the minimum and maximum given in parentheses.