TABLE 5

Mean maximum viral load reduction influenced by dose of EDP-239

EDP-239 dose (mg) or placeboMaximum HCV RNA reduction (log10 IU/ml) (mean ± SD)a
GT1aGT1b
102.08 ± 0.78 (d2)3.90 ± 0.33 (d4)
302.32 ± 1.50 (d2)3.50 ± 0.76 (d3)
1003.58 ± 0.75 (d3)4.36 ± 0.11 (d5)
2003.39 ± 0.21 (d3)b3.80 ± 0.73 (d5)
Placebo0.20 ± 0.16 (d4)0.17 ± 0.49 (d3)
  • a The day of measurement is indicated in parentheses (e.g., d2 indicates day 2).

  • b This value excludes results for one patient with an HCV RNA level of <105 IU/ml at baseline.