TABLE 2

NS5A RAMs detected at baseline in GT1 patients by deep sequencing

HCV genotypeDose (mg)PatientBaseline RAMRAM frequency (%)Maximum RNA reduction (log10 IU/ml)
PatientCohort mean
1a105306M28V22.912.08
105310K24R22.54
M28V2
105314K24R41.21
Q30H44
105407aM28V231.68
H58R2
Y93F28
305313Q30R41.422.32
1005308M28V22.743.58
2005304M28V293.243.39b
2005305K24N30.56
K24R3
K24S1
M28T90
Q30H56
Q30L2
Q30R13
F36L99
H58D1
H58R1
2005309M28V433.58
E62V25
1b105404Y93H44.143.90
305414Y93H992.793.50
1005402R30Q764.374.36
2005403P58S994.023.80
2005411R30Q1002.99
Q62R100
  • a Incorrectly identified as infected with GT1b HCV at screening.

  • b Results for patient 5305 excluded from mean calculation due to viral RNA level of <105 IU/ml at baseline.