TABLE 3

Numbers of patients with NS5A RAMs detected by deep sequencing across dosing cohorts at nadir viral RNA level

GenotypeMutationNo. of GT1a or GT1b patients receiving indicated dose of EDP-239 with NS5A RAMs at nadir
10 mg30 mg100 mg200 mg
1aK24R21
K24N1
M28A1
M28T2321
M28V3112
Q30H431
Q30E13
Q30R3333
L31M3
L31V1
F36L11
H58D321
H58L1
H58C1
A92T2
Y93C2211
Y93F1
Y93H2212
Y93N11
Y93S1
1bL28M1
R30Q111
R30H1
L31F1
L31V2
L31M1
P58S11
Q62P1
Q62R1
A92K1
Y93C111
Y93H121
Y93N1