TABLE 6

Persistence of NS5A RAMs through postdose week 12, 24, or 48

GTDosePatientRAM(s) persistent up to wk 48 (%)a
1a105306UNK
105310Q30H(1)/R(37), L31M(43), H58D(2), Y93N(7)/C(8)
105314Q30H(56)/R(13), F36L(1)
105407bK24R(2), M28V(66), Q30H(8)/R(80), L31M(2), H58C(15)/D(2), Y93F(12)
305303Q30H(14)/R(79), H58D(3)
305307ND
305313UNK
1005301M28T(2), L31M(77)
1005308M28T(5)/V(4), Q30H(2)/R(78), L31M (1), Y93C(2)
1005311cM28T(63), Q30R(53)
2005304UNK
2005305UNK
2005309UNK
1b105404UNK
105409ND
305405Y93H(3)
305413cND
305414Y93H(99)
1005402L28 M(6), R30Q(16), L31 M(35), Y93H(37)/N(45)
1005406bR30G(3), L31V(46)/M(2), Y93H(4)
1005410L31M(12), Y93H(10)
2005403UNK
2005408cL31V(2)/M(97), Y93H(92)
2005411bL28 M(58), R30Q(5)/H(95)
  • a UNK, no data for week 12, 24, or 48; ND, no RAMs detected.

  • b Week 12 persistence.

  • c Week 24 persistence.