TABLE 3

Summary of ceftazidime and avibactam pharmacokinetic parameters measured in pediatric patients (pharmacokinetic population)

Drug and parameteraValue for cohort:
1 (n = 8) (≥12 to <18 yr)2 (n = 8) (≥6 to <12 yr)3 (n = 8) (≥2 to <6 yr)4 (n = 8) (≥3 mo to <2 yr)
Ceftazidime
    Cmax (mg/liter)79.8 (41.8)81.3 (17.8)80.1b (14.7)91.7b (19.6)
    tmaxc (h)2.0 (1.9–2.6)2.1 (1.9–2.4)
    AUC0–t (h · mg/liter)229.2 (30.9)217.8 (18.4)
    AUC0–∞ (h · mg/liter)230.6 (30.7)221.2 (17.4)
    t1/2c (h)1.7 (0.9–2.8)1.6 (0.9–1.8)
    Vss (liters)22.2 (42.0)13.0 (17.8)
    CL (liter/h)8.7 (45.5)5.6 (16.0)
    CL/W (liter/kg/h)0.169 (37.9)0.226 (20.0)
Avibactam
    Cmax (mg/liter)15.1 (52.4)14.1 (23.0)13.7b (22.4)16.3b (22.6)
    tmax (h)2.0 (1.9–2.6)2.1 (1.9–2.4)
    AUC0–t (h · mg/liter)36.3 (33.7)34.4 (23.4)
    AUC0–∞ (h · mg/liter)36.4 (33.6)34.8 (22.6)
    t1/2 (h)1.6 (0.9–2.8)1.7 (0.9–2.0)
    Vss (liters)31.0 (53.3)19.3 (27.0)
    CL (liter/h)13.7 (52.6)8.9 (30.2)
    CL/W (liter/kg/h)0.267 (44.2)0.359 (35.8)
  • a Values are geometric mean (coefficient of variation [%]) unless stated otherwise. CL/W, weighted clearance or clearance by body weight.

  • b Plasma concentration as measured at end of infusion.

  • c Median (range).