TABLE 6

In vitro frequencies of resistancea

CompoundResistance frequency at:
4× MIC10× MIC
Compound 144.6 × 10−63.9 × 10−6
IsoniazidND1.8 × 10−5
Moxifloxacin1.7 × 10−71.1 × 10−8
  • a The MIC values for compound 14, isoniazid, and moxifloxacin on Middlebrook 7H10 agar were determined to be 0.2, 0.06, and 0.08 μg/ml, respectively. ND, not determined.