TABLE 2

Characterization of different H37Rv dprE1 mutantsa

MutationCodonColony sizePresence of BTZ in plate from which colonies were pickedMutation(s) identified by sequencingBTZ043 MIC (μg/ml)RIF MIC (μg/ml)
C387TGC (WT)0.00080.0016
C387STCCNormalBTZ043C387S≥100.0016
C387AGCCNormalBTZ043C387A>100.0016
C387TAATNormalBTZ043C387T>100.0016
C387GGGCSmallC387GUndet.Undet.
NormalC387G V388I50.0008
C387NACCSmallC387N1.250.0008
NormalC387T*>100.0016
  • a RIF, rifampin; Undet., undetermined. * indicates the C387T mutation with an ACT codon.