TABLE 3

PBTZ169 and Ty38c MICs for H37Rv and H37Rv dprE1 C387 mutant strains

StrainPBTZ169 MIC (μg/ml)Ty38c MIC (μg/ml)RIFa MIC (μg/ml)
H37Rv0.00010.10.001
C387S>10.50.001
C387G0.50.040.0005
C387A>10.10.001
C387T>10.80.001
C387N0.60.10.001
NTB1b>10.70.001
  • a RIF, rifampin.

  • b BTZ-resistant strain with a C387S mutation (control).