TABLE 1

Validation compounds and chemical and target information for the selected validation compounds

Compound IDaPutative target/mode of actionbCompound classReference
ELQ-300*bc1 complex4(1H)-Quinolone84
Antimycin Abc1 complex (Qi site)Other119
Atovaquonebc1 complex (Qo site)Naphthoquinone61
Myxothiazolbc1 complex (Qo site)Other120
P218*DHFR2,4-Diaminopyrimidine89
PyrimethamineDHFRAntifolate87
WR99210DHFRAntifolate88
DSM265*DHODHTriazolopyrimidine86
DSM1DHODHTriazolopyrimidine121
2-DeoxyglucoseHexokinase and phosphoglucoisomeraseOther122
OZ277*Peroxide mediatedTrioxane123
OZ439*Peroxide mediatedTrioxane95
KAE609*PfATP4Sprioindolone36
(+)-SJ733*PfATP4Dihydroisoquinolone64
KAF246PfATP4Spiroindolone37
KAF156*PfCARLImidazolopiperazine39
ChloroquinePfCRT4-Aminoquinonlone124
MMV390048*PfPI4KAminopyridine91
DDD498*Translation elongation factor 2Quinoline-4-carboxamide40
AZ412*Vacuolar ATP synthase (V-type H+-ATPase) subunit DTriaminopyrimidine92
  • a MMV lead compounds are denoted with an asterisk.

  • b DHFR, dihydrofolate reductase; DHODH, dihydroorotate dehydrogenase.