TABLE 2

In vitro MICs of various antibiotics against wild-type and permeable P. aeruginosa strains

AntibioticMB5919MB5890
MIC (μg/ml)Fold changeMIC (μg/ml)Fold change
WTMutantWTMutant
lptD4213lptD208lptD4213lptD208
Clindamycin>256>256256NCa8442
Linezolid>256>256>256NC4441
Imipenem410.54–820.512–4
Vancomycin>2566432>4–8>256128128>2
Colistin10.1250.254–80.50.1250.1254
Rifampin320.50.564321132
Tetracycline1620.58–320.250.1250.1252
Ciprofloxacin20.06250.03232–640.0040.0040.0041
Novobiocin>25688>32641232–64
Carbenicillin16244–840.1250.12532
Fusidic acid>256>256128>2642232
Azithromycin2562212880.1250.12564
Gentamicin0.50.1250.252–40.50.250.51–2
  • a NC, not calculated due to lack of activity at the highest concentration tested.