TABLE 3

In vitro MICs of β-lactam antibiotics against oprD mutant P. aeruginosa strains with and without permeability-inducing alleles

AntibioticMB6477MB6476
MIC (μg/ml)Fold changeMIC (μg/ml)Fold change
WTMutantWTMutant
lptD4213lptD208lptD4213lptD208
Imipenem160.50.5328118
Carbenicillin321216–3240.1250.12532