TABLE 4

Cocarriage of metallo-β-lactamases and serine β-lactamases in Enterobacteriaceae and P. aeruginosa collected from 2012 to 2014a

MBL and serine β-lactamaseOrganismNo. of isolatesMolecular variant(s)
MBL + KPCK. pneumoniae1VIM-1, KPC-2
MBL + KPC + ESBL + AmpC + OSBLbK. pneumoniae2VIM-1, KPC-2, SHV-12, CMY-13, TEM-OSBL
MBL + KPC + ESBLK. oxytoca2IMP-4, KPC-2, SHV-12
MBL + KPC + AmpCP. aeruginosac1VIM-2, KPC-2
MBL + KPC + AmpC + OSBLK. pneumoniae1VIM-1, KPC-2, MOX-1, SHV-OSBL
MBL + OXA carbapenemase + ESBL + AmpC + OSBLE. cloacaec1VIM-4, OXA-48, SHV-12, CMY-4, TEM-OSBL
MBL + OXA carbapenemase + ESBL + OSBLK. pneumoniae3NDM-1, OXA-48, CTX-M-15, SHV-OSBL
MBL + OXA carbapenemase + AmpCE. cloacaec1VIM-4, OXA-48, CMY-4
1VIM-31, OXA-48
MBL + OXA carbapenemase + OSBLK. pneumoniae1NDM-1, OXA-232, SHV-OSBL
MBL + ESBL + AmpC ± OSBLC. freundiic1IMP-8, SHV-12, TEM-OSBL
2VIM-1, SHV-12
1VIM-4, CTX-M-15, TEM-OSBL
1NDM-1, CTX-M-3, SHV-12, TEM-OSBL
E. asburiaec1IMP-8, SHV-12, TEM-OSBL
1NDM-1, VEB-1, TEM-OSBL
E. cloacaec1IMP-8, SHV-12, TEM-OSBL
1IMP-8, CTX-M-22, TEM-OSBL
1VIM-1, CTX-M-14, TEM-OSBL
1NDM-1, CTX-M-15
4NDM-1, CTX-M-15, TEM-OSBL
2NDM-1, CTX-M-15, SHV-31, TEM-OSBL
K. oxytocad1VIM-1, ACC-1
1NDM-1, ACC-1, TEM-OSBL
K. pneumoniae1IMP-26, CTX-M-15, DHA-1, SHV-OSBL, TEM-OSBL
1NDM-1, CTX-M-15, CMY-6, SHV-OSBL, TEM-OSBL
1NDM-1, CTX-M-15, CMY-6, DHA-type, SHV-OSBL, TEM-OSBL
P. stuartiic1VIM-1, SHV-5, TEM-OSBL
3VIM-1, SHV-5, VEB-1, TEM-OSBL
S. marcescensc2NDM-1, CTX-M-15, TEM-OSBL
P. aeruginosac1VIM-2, SHV-2A
2VIM-2, SHV-12
1VIM-2, GES-1
4VIM-2, PER-1
1VIM-2, VEB-1b
1VIM-2, VEB-1
1VIM-4, SHV-12
1VIM-5, PER-1
2VIM-5, VEB-14e
2VIM-45, VEB-1bf
2NDM-1, VEB-1a
MBL + ESBL ± OSBLE. coli1NDM-1, CTX-M-3
1NDM-1, CTX-M-27
K. oxytocad1IMP-4f
2VIM-1
K. pneumoniae1IMP-1, CTX-M-3, SHV-OSBL
2IMP-4, CTX-M-15, SHV-OSBL
1IMP-4, CTX-M-15, SHV-OSBL, TEM-OSBL
1IMP-26, CTX-M-15, SHV-28
1IMP-26, CTX-M-15, SHV-OSBL
1IMP-26, CTX-M-15, SHV-OSBL, TEM-OSBL
2VIM-1, SHV-12
2VIM-4, CTX-M-15, SHV-OSBL, TEM-OSBL
1VIM-26, SHV-5
1VIM-42, SHV-12
1NDM-1, CTX-M-15
9NDM-1, CTX-M-15, SHV-OSBL
16NDM-1, CTX-M-15, SHV-OSBL, TEM-OSBL
1NDM-1, CTX-M-15, SHV-12
1NDM-1, CTX-M-15, SHV-12, TEM-OSBL
1NDM-1, CTX-M-15, SHV-55, TEM-OSBL
1NDM-1, CTX-M-15, SHV-134, TEM-OSBL
1NDM-1, CTX-M-15, CTX-M-27, TEM-OSBL
1NDM-5, CTX-M-15, SHV-OSBL, TEM-OSBL
2NDM-7, CTX-M-15, SHV-12, TEM-OSBL
1NDM-16, CTX-M-15, SHV-OSBL, TEM-OSBL
1NDM-16, CTX-M-15, SHV-12, TEM-OSBL
P. mirabilis1VIM-1, SHV-5, VEB-1, TEM-OSBL
1VIM-1, VEB-1, TEM-OSBL
MBL + AmpC ± OSBLC. freundiic2IMP-8, TEM-OSBL
1VIM-1
1VIM-23
1VIM-32
1NDM-7, DHA-1
1NDM-7, TEM-OSBL
E. aerogenesc1VIM-23
E. asburiaec1IMP-14
1NDM-7
E. cloacaec2IMP-1
1IMP-4
6VIM-1
7VIM-1, TEM-OSBL
2VIM-23
2NDM-1, DHA-1, TEM-OSBL
1NDM-7
E. coli1VIM-1, ACT-24, TEM-OSBL
1NDM-5, CMY-42
1NDM-5, CMY-42, TEM-OSBL
P. mirabilis1IMP-26, DHA-1
2VIM-1, CMY-16, TEM-OSBL
P. rettgeric1NDM-1, TEM-OSBL
P. stuartiic1VIM-1, CMY-2
S. marcescensc1IMP-47, TEM-OSBL
1VIM-4
1VIM-5
P. aeruginosac6IMP-1
1IMP-1, TEM-OSBL
2IMP-6
8IMP-7
1IMP-13
1IMP-14
1IMP-16
2IMP-18
1IMP-19
5IMP-26
6IMP-48
1IMP-49
6VIM-1
228VIM-2
1VIM-2, TEM-OSBL
11VIM-4
2VIM-5
1VIM-6
2VIM-28
1VIM-43
1VIM-44
1NDM-1
MBL + OSBLE. coli1VIM-1, SHV-OSBL
K. pneumoniae1IMP-1, SHV-OSBL
1IMP-4, SHV-OSBL, TEM-OSBL
1IMP-4, TEM-OSBL
1IMP-8, SHV-OSBL
8VIM-1, SHV-OSBL
4NDM-1, SHV-OSBL
1NDM-5, SHV-OSBL
  • a Serine β-lactamases were not detected by PCR in 6 MBL-positive Enterobacteriaceae isolates (1 K. pneumoniae isolate and 5 P. mirabilis isolates).

  • b OSBL, original spectrum β-lactamase; includes TEM-1, TEM-2, SHV-1, and SHV-11.

  • c Presumed to also carry the intrinsic chromosomally encoded AmpC β-lactamase common to this species.

  • d Presumed to also carry the intrinsic chromosomally encoded ESBL common to this species.

  • e S. Lahiri (formerly of AstraZeneca Pharmaceuticals), personal communication.

  • f The full gene sequence was determined by whole-genome sequencing.