TABLE 5

Antibiotic susceptibility of E. coli, E. aerogenes, and K. pneumoniae strains and combination with the efflux blocker (PAβN 20 mg/liter)

StrainMIC (mg/liter)a
CHLCHL + PAβNPAβNAVICAZCAZ + PAβNAVI + PAβNCAZ + AVI 1 + PAβNCAZ + AVI 2 + PAβN
E. coli
    AG10082512160.51320.5ND
    ARS1002566451212810.5320.5ND
    ARS10851232256323232320.5ND
    ARS14432225681,024128168ND
    ARS1508425685121281611
    ARS23764825632128128322ND
    ARS2731,0246451281281281628
    ARS301161512162,0482561616ND
E. aerogenes
    ATCC 15038411,02480.060.125160.1250.125
    EA25121281,0244256128842
    EA35121281,024641,0241,02412816ND
    EA52561281,024641,0241,0246464ND
    EA275121281,0242561,0241,02451212864
    EA1175122561,0241281,0241,024643216
    EADFJ 851,024641,024165121,0246416ND
    EADFJ 461,024641,0241281,0241,024>1,024>128ND
K. pneumoniae
    ATCC 112964142560.250.51280.50.5
    KP451621,0241280.50.5640.5ND
    KP551621,0241281281282563232
    KP635121281,024165125123232ND
    KP7481512642,0481,024646464
    KP8012881,024168163244
    KP89128321,024821161ND
  • a CHL, chloramphenicol; PAβN, phenylalanine-arginine β-naphthylamide; AVI, avibactam (1 or 2 mg/liter); CAZ, ceftazidime; ND, not determined.