TABLE 3

Pharmacokinetic resultsa

Screening no.AUC0–8 (mg · h/liter) prefilterCltot (liters/h)Clpre-post filter (ml/min)ScClSc (ml/min)Vt1/2β (h)
Total (liters)Corrected for body wt (liters/kg)
171.969.5323.260.1233.3257.750.654.19
258.657.4230.610.1465.09135.901.7612.69
367.508.9335.750.2729.4176.820.855.96
489.899.0026.610.1846.2641.560.423.20
581.587.6233.120.1956.5054.370.724.94
684.326.9347.230.1535.0941.550.264.15
795.287.5369.650.1687.2640.870.583.76
887.595.1429.970.0642.3059.220.707.98
981.648.2424.240.1042.9751.150.514.30
1071.9511.3120.700.1764.5151.710.863.13
11cc42.060.1397.66ccc
1379.025.5357.980.0893.6361.220.607.67
1473.629.7333.630.1286.1239.010.522.78
Mean ± SD
    All patientsb78.58 ± 10.328.07 ± 1.7736.06 ± 14.270.150 ± 0.0535.20 ± 1.9559.26 ± 26.470.70 ± 0.365.39 ± 2.84
    Patients on CVVH (n = 3)87.15 ± 8.136.53 ± 1.0063.82 ± 5.830.129 ± 0.0336.45 ± 1.8151.05 ± 10.180.59 ± 0.015.72 ± 1.96
    Patients on CVVHD (n = 5)77.59 ± 12.317.48 ± 1.4334.03 ± 7.220.164 ± 0.0675.63 ± 2.3071.01 ± 34.980.80 ± 0.526.80 ± 3.37
    Patients on CVVHDF (n = 5)76.15 ± 4.509.29 ± 1.2826.99 ± 5.340.145 ± 0.0354.68 ± 1.4350.80 ± 6.340.65 ± 0.133.87 ± 0.80
  • a Prefilter, measured in the blood before it enters the filter (concentrations are as found in the patient); Cltot, total body clearance; Clpre-post filter, clearance calculated by the hemofilter inlet/outlet-based formula described in Materials and Methods; Sc, sieving/saturation coefficient; ClSc, clearance calculation based on the sieving coefficient. The dose for each patient was 1 g doripenem q8h.

  • b Except for patient 11, whose values were excluded from the calculation of means.

  • c —, values for patient 11 have been excluded from calculation of means (absolute concentrations too low due to storage at -20°C). The same error may affect calculated values as the clearance and sieving coefficient values, which are given due to the fact that they are calculated as relative values.