TABLE 4

Population pharmacokinetic parameter estimatesa

ParameterEstimateRSE (%)IIV (%)Bootstrap valueb (n = 1,000)
Cltot (liters/h)9.791550.59.96 (7.92–13.2)
V1 (liters)43.52164.843.43 (30.3–64.3)
Q (liters/h)27.1150 FIXc30.75 (21.8–53.8)
V2 (liters)29.52481.830.35 (16.2–44.2)
Residual error
    Proportional0.23110.22 (0.15–0.27)
    Additive0.89320.99 (0.6–1.86)
  • a RSE, relative standard error; IIV, interindividual variability.

  • b Given as mean (95% confidence interval).

  • c 0 FIX, IIV could not be estimated by the model and was set to 0 in the final model.