TABLE 3

Effects of the EPIs BM-19 and BM-38 on various antibiotic MICs

StrainMIC (mg/liter)a
LevofloxacinTetracyclineChloramphenicolRifampinOxacillinLinezolidClarithromycin
3-AG100 without EPI141616512512128
3-AG100 + 25 μM BM-19141616512256128
3-AG100 + 50 μM BM-19 (1/4 MIC)0.13120.5646416
3-AG100 + 25 μM BM-38 (1/4 MIC)1484256256128
3-AG100 + 50 μM BM-381282256256256
3-AG100 ΔacrB without EPI0.030.25181161
3-AG100 ΔacrB + 25 μM BM-190.030.13111160.5
3-AG100 ΔacrB + 50 μM BM-190.03≤0.0610.13≤0.581
3-AG100 ΔacrB + 25 μM BM-380.03≤0.0610.13≤0.58≤0.5
PA1426 without EPI1256128322,0482,048256
PA1426 + 100 μM BM-19 (1/4 MIC)2256128162,0482,048256
PA1426 + 100 μM BM-38 (1/4 MIC)2256128162,0482,048256
PA1425 without EPI0.0616216646416
PA1425 + 100 μM BM-19 (1/4 MIC)0.0616216128328
PA1425 + 100 μM BM-38 (1/4 MIC)0.061621664328
  • a MICs which differed at least 4-fold in the presence of BM-19 or BM-38 from the MIC of the AcrAB-TolC-overproducing strain 3-AG100 in the absence of these compounds are given in bold.