TABLE 3

Initial rates of hydrolysis for NDM-1, NDM-1I35T, and NDM-1I35S at different concentrations of ZnCl2

Enzymev0 (mmol min−1 mg−1)a
0 μM Zn2+20 μM Zn2+50 μM Zn2+100 μM Zn2+
NDM-159130134130
NDM-1I35T27807070
NDM-1I35S9999107103
  • a Rates of hydrolysis (v0) are expressed in millimoles per milligram of imipenem (100 μM) hydrolyzed per minute per milligram of enzyme.