TABLE 5

Patterns of β-lactam resistance mediated by NDM-1, NDM-1I35S, and NDM-1I35T in E. coli JM109(DE3) in comparison with the pattern in E. coli JM109(DE3)/pET-24(a)

β-LactamMIC (μg/ml)
E. coli JM109(DE3)/pSP-NDM-1E. coli JM109(DE3)/pSP-NDM-1I35SE. coli JM109(DE3)/pSP-NDM-1I35TE. coli JM109(DE3)/pET-24(a)
Imipenem>64>64>640.5
Meropenem>64>64>640.5
Biapenem1616640.125
Cefazolin256128256<0.0625
Cefotaxime1283264<0.0625
Ceftazidime256128256<0.0625
Cefoxitin81632<0.125
Cefepime321632<0.0625
Loracarbef128128128<0.0625
Cefaclor64641280.5
Moxalactam643264<0.125
Benzylpenicillin512256>5120.5
Carbenicillin512256>5120.5