TABLE 2

VT-1129 MICs against Cryptococcus gattii isolatesa

ParameterMIC for agent (endpoint)
Cumulative (n = 321)CDC (n = 300)UTHSCSA (n = 21)
VT-1129 (50%)VT-1129 (100%)VT-1129 (50%)VT-1129 (100%)VT-1129 (50%)VT-1129 (100%)
Range≤0.015–10.06–>8≤0.015–10.06–>8≤0.015–0.250.06–1
Mode0.12510.2510.1250.25
MIC500.12510.12510.060.25
MIC900.2520.2520.1250.5
GM MICb0.07820.75730.08040.81120.05340.2842
  • a All MICs were measured after 72 h of incubation at 35°C and read at 50% and 100% inhibition of growth compared to growth control.

  • b GM MIC, geometric mean MIC.