TABLE 3

VT-1129 MICs against Cryptococcus gattii isolates by molecular typea

EndpointMIC (μg/ml)
50%100%
VGI (n = 45)
    Range≤0.015–0.50.125–8
    Mode0.0150.25
    MIC500.030.5
    MIC900.1251
    GM MICb0.04320.4019
VGII (n = 7)
    Range0.06–0.250.5–2
    Mode0.250.5–1
    MIC500.251
    MIC900.251
    GM MIC0.15060.8203
VGIIa (n = 104)
    Range0.06–0.50.5–2
    Mode0.1251
    MIC500.1251
    MIC900.25–22
    GM MIC0.13320.9477
VGIIb (n = 20)
    Range0.06–0.50.5–2
    Mode0.125–0.252
    MIC500.1252
    MIC900.252
    GM MIC0.17611.319
VGIIc (n = 32)
    Range0.06–10.5–4
    Mode0.252
    MIC500.252
    MIC900.252
    GM MIC0.21871.874
VGIII (n = 20)
    Range≤0.015–0.250.25–2
    Mode0.1251
    MIC500.1251
    MIC900.251
    GM MIC0.11110.8123
VGIV (n = 72)
    Range≤0.015–0.250.125->8
    Mode0.0150.5
    MIC500.0150.5
    MIC900.062
    GM MIC0.02530.6019
  • a All MICs were measured after 72 h of incubation at 35°C. VT-1129 MICs were read at 50% and 100% inhibition of growth compared to growth control.

  • b GM MIC, geometric mean MIC.