TABLE 2

IC50s for sofosbuvir in genotypes 1b (Con1), 3a (S52), and 4a (ED43)

Cell lineRepliconMean IC50 ± SDa
48 h p.e.72 h p.e.96 h p.e.
Huh7.51b/L-GDD
1b/l-GDD
3a/LN-GDD48 ± 442 ± 157 ± 2
3a/L-GDD53 ± 847 ± 940 ± 2
4a/LN-GDD
4a/l-GDD49 ± 27
231b/L-GDD
1b/l-GDD95 ± 842 ± 455 ± 6
3a/LN-GDD35 ± 338 ± 629 ± 1
3a/L-GDD42 ± 341 ± 229 ± 1
4a/LN-GDD28 ± 10
4a/l-GDD45 ± 1539 ± 1
  • a IC50s are the concentrations of sofosbuvir that inhibit the HCV replicon by 50%. —, not determined (insufficient replication).