TABLE 1

MICs of CAM-resistant BLNAR and CAM-susceptible BLNAR H. influenzae

StrainMIC (μg/ml)a
CLRCLR + CCCPat:CLR + PAβNat:AZMAZM + CCCP at:AZM + PAβN at:MINNOREB
0.751.525500.751.52550
124-2010321613216420.13220.250.0318
54-2011321643216420.5220.250.0314
70-201132164168410.25210.250.0318
72-20113216116841≤0.06210.250.0638
82-201132160.5168420.13220.50.0318
42-201232164328841420.50.031≥16
46-201232164168420.5210.50.0168
130-2011111110.13≤0.06≤0.06≤0.06≤0.06≤0.060.0082
ATCC 49247221220.250.25≤0.060.250.250.130.0162
H. influenzae Rd840.25880.50.5≤0.06110.130.0161
  • a CLR, clarithromycin; AZM, azithromycin; MIN, minocycline; NOR, norfloxacin; EB, ethidium bromide; CCCP, carbonyl cyanide m-chlorophenylhydrazone; PAβN, phenylalanine-arginine β-naphthylamide. Concentrations are given for the second drug listed in combinations and are measured in micrograms per milliliter.