TABLE 2

Blood pharmacokinetic parameters in BALB/c mice after single oral gavage administration of compound 1

ValueActual dose (mg/kg of body weight)Cmax (ng/ml)Cmax/Da (kg · ng/ml/mg)AUCall (h · ng/ml)AUC observed (h · ng/ml)AUC/D observedb (h · kg · ng/ml/mg)
By animal ID
    150227.04.5401.0438.18.8
    250154.03.1339.7358.47.2
    35095.91.9227.6238.84.8
Overall
    Average159.03.2322.8345.16.9
    SDc65.71.387.9100.32.0
  • a Cmax/D, dose-normalized value of Cmax (Cmax/experimental dose).

  • b AUC/D, dose-normalized value of AUC (AUC/experimental dose).

  • c SD, standard deviation.