TABLE 3

Activity of liposomal amphotericin B, miltefosine, and compound 1 against BALB/c mice infected with L. donovani HU3 (n= 5)

Tested compoundAdministration% inhibition95% CIa
Liposomal amphotericin B1 mg/kg i.v. (days 7, 9, and 11)99.520.28
Miltefosine12 mg/kg p.o. × 5 days77.2312.41
Compound 150 mg/kg BIDb × 5 days20.938.34
  • a CI, confidence interval.

  • b BID, twice a day.