TABLE 1

Mefloquine PK key parameters in NOD SCID IL-2Rγ−/− mice

ParameteraEstimateRelative SE95% confidence interval
Theta
    Ka0.34/h260.17–0.51
    V2,810 ml/kg37772–4,580
    CL162 ml/h/kg14117–207
    V25,110 ml/h/kg153,640–6,580
    Q2,730 ml/h/kg2.82,580–2,880
    F0.56%160.39–0.73
Eta
    Ka0.2839
    V0.6150
    CL0.06531
Sigma
    PK0.0319
  • a CL, clearance; F, extent of absorption or bioavailability; Ka, absorption rate constant; Q, intercompartmental clearance; V, central volume; V2, peripheral volume. See supplemental material for other model parameters.