TABLE 2

Mefloquine PD key parameters in NOD SCID IL-2Rγ−/− mice

ParameteraEstimateRelative SE95% confidence intervalDerived parameterEstimate95% confidence interval
Theta
    G0.03124.50.029–0.034Growth rate0.65/48 h0.59–0.71
    Dmax0.189220.11–0.27Death rate3.94/48 h2.2–5.7
    k0.00892/h300.0036–0.014Log10 PRR483.29
    IC500.768 μg/ml8.30.64–0.89
    H1.81250.94–2.68
    BL0.376% parasitemia10.369–0.383
Eta
    G0.1540
    BL0.04626
Sigma
    PD0.0364
  • a Dmax, maximal death rate; G, growth rate; H, Hill coefficient; k, exponential rate constant describing the acceleration of parasitemia elimination; BL, basal level. See supplemental material for other model parameters.