TABLE 2

Survival and physical activity of different groups of BALB/c mice at different time points after commencement of the experiments

TreatmentPhysical activity of each of the five animals ata:
4 h8 h12 h24 h48 h72 h120 h168 h
Saline1111111111111111111111111111111111111111
LPS (12 mg/kg)33333334443344455†††††††††††††††††††††††
LPS + I16A-piscidin-1 (1 mg/kg)333332233322223222241112†1111†1111†1111†
LPS + I16A-piscidin-1 (2 mg/kg)2233322222222221111111111111111111111111
I16A-piscidin-1 (5 mg/kg)1111111111111111111111111111111111111111
  • a Groups of animals (n = 5 each) were inoculated intraperitoneally with LPS (12 mg/kg) alone, LPS (12 mg/kg) and 1 mg/kg or 2 mg/kg of I16A-piscidin-1, or 5 mg/kg I16A-piscidin-1 or saline alone. The data indicate the physical activity of each of the five animals at the indicated time point rated according to the following criteria: 1, very active; 2, active; 3, less active; 4, slow; 5, lethargic; †, dead.