TABLE 3

Comparison of substance-specific therapeutic indices and toxic areas

Substance therapeutic area (unit)CaSO4-G (Herafill-G) (gentamicin)CaSO4-V (vancomycin)Osteoset (tobramycin)
Total substance mass implanted (mg)54.914.3
Therapeutic index (μg/ml)4–125–404–8
Toxic area (μg/ml)>10–12>80>12