TABLE 1

Il-6 levels in the mice shown in Fig. 1 after 8 h of infection

Strain tested (MIC) and antibiotic dose (mg/kg)Mean IL-6 amt (μg/ml)aP valueb
LNP24198lux (0.125 mg/liter)
    Untreated10.4 (3.8 to 16.9)
    5014.4 (−8.1 to 36.9)
    1001.8 (−0.7 to 4.2)
    200ND
LNP27704lux (1.5 mg/liter)
    Untreated2.8 (0.6 to 5)0.01
    504.2 (0.6 to 7.7)0.25
    1004.3 (0.1 to 8.5)0.2
    200ND
  • a Values in parentheses are 95% confidence intervals. ND, nondetectable.

  • b P values were determined for the difference between results with the Pens isolate (LNP24198lux), used as a reference, and those with the Penr isolate (LNP27704lux).