TABLE 1

MICs of antibiotics for tested organisms and DAP MICs in combination with TOL-TAZ, TOL, TAZ, or CFZ

StrainMIC (μg/ml)
DAPTOL-TAZ-4aTOL-TAZ-23.8aTOLCFZDAP+TOL-TAZ-4bDAP+TOLbDAP+TAZbDAP+CFZb
R88450.5128/4128/23.28128320.250.50.50.06
R8846432/432/23.83224440.25
  • a Ceftolozane-tazobactam MICs were obtained with static tazobactam concentrations of both 4 μg/ml (TAZ-4) (CLSI standard) and 23.8 μg/ml (TAZ-23.8) (fCmax of tazobactam).

  • b For combination MICs, TOL-TAZ, TOL, and CFZ were present in broth at 0.5× the reported MIC for each organism.